Lab News

  • August, 2017 – The best of luck and a big thank you to Dr. Adam Konopka for all of his work in the lab. Dr. Konopka is off to University of Illinois at Urbana-Champaign to start a research program as an assistant professor in the College of Applied Health Sciences. Congratulations and good luck Adam!
  • August, 2017 – The NIH awarded the lab with an R21 grant investigating the “Dual treatment of sarcopenia and osteoarthritis with a Nrf2 activator” with Dr. Kelly Santangelo as Co-Principal Investigator!
  • July, 2017 - Registration is now open for the Front Range Consortium on Aging Research: Accelerating Translation of Aging Treatments. Hurry! registration is free but space is limited!
  • July, 2017 - Mary Scott Lecture Series presents "Learn more about healthy aging in people and their pets." Free and open to the public! Click here for details.
  • July, 2017 - Thank you Hayden for your hard work and service! Best of luck on your worldly travels!
  • June, 2017 - Congratulations Jaime Laurin for your successful masters thesis defense!
  • June, 2017 - TRACD was recently awarded a NIH R01 with Drs. Esther Dupont-Versteegden and Tim Butterfield at the University of Kentucky - Mechanisms underlying anabolic effects of cyclic compressive loading in muscle.
  • June, 2017 - TRACD was recently awarded a NIH SBIR with Pathways Bioscience- Supporting Healthy Aging with a Phytochemical Combination that Acts at Multiple Control Points in the Nrf2 Activation Pathway
  • June, 2017 - Welcome Zack Valenti and Andrew Platt on your acceptance for the Department of Defense URAP summer fellowship!
  • June, 2017 - TRACD will hosting Andy Holwerda from Dr. Luc Van Loon’s Lab and Leslie Baehr from Dr. Sue Bodine’s Lab!

What we study and how we study it!

We take an integrative approach to studying age-associated chronic diseases. We are primarily focused on how to maintain muscle, both skeletal and cardiac, over the lifespan. Special areas of focus include proteostatic mechanisms, mitochondria, redox balance, protein stability, and hypoxia. Finally, we focus on strategies that incorporate nutritional strategies as well as exercise for the prevention and treatment of chronic disease.

Through the combined expertise of the lab co-directors we are able to address research questions using cell culture, animal models, in vivo human studies, and clinical interventions. We have established cardiac, skeletal muscle, and human coronary endothelial cell models. Additionally, we use long-lived animal models and animal models for hypoxia, myocardial ischemia-reperfusion, exercise training, and voluntary physical activity. In human subjects we rely on stable isotopic tracer techniques as well as tissue sampling. Cells and tissues are analyzed using a variety of biochemical and molecular techniques.

Lab Updates